ANTIDIABETIC AND HYPERINSULINEMIC EFFECTS OF FENUGREEK AND TERMIS SEEDS AQUEOUS EXTRACTS IN EXPERIMENTAL RATS

Authors

  • M. MARZOUK Zoology Department, Faculty of Science, Cairo University, Egypt
  • T. Y. OMAR Zoology Department, Faculty of Science, Sirt University, Libya
  • A. M. SOLIMAN Zoology Department, Faculty of Science, Cairo University, Egypt

DOI:

https://doi.org/10.53555/eijas.v1i3.13

Keywords:

Fenugreek, Termis, Streptozotocin, Diabetic rats, insulin

Abstract

To investigate antidiabetic efficacy of Fenugreek (F) and Termis (T) seeds aqueous extracts in streptozotocine induced diabetes in rats. Experimental diabetes was induced by intraperitoneal injection of a single dosage of STZ (50 mg/kg, i.p.). Adult male rats were divided into five groups; (1) normal control, (2) diabetic control, (3) diabetic-F supplement (1 g/kg b. wt.), (4) diabetic-T supplement (1 g/kg b. wt.) and (5) diabetic- mixture (M) supplement (1 g/kg b. wt.) of each seed extracts concurrently for 30 days. The decreased insulin, plasma GSH, GST, CAT, as well as liver and muscle glycogen content and increased serum glucose, total lipids, triglycerides, total cholesterol, creatinine, urea, uric acid, AST, ALT, and ALP were the salient features recorded in diabetic control rats. This study showed that the regular intake of the T. foenum graecum, L. albus seeds water extract and their mixture can improve antioxidant status and considered as an effective agent in modulating the alterations due to diabetes.

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Published

2015-09-27

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Vol. 1 No. 3 (2015): EPH - International Journal of Applied Science ( ISSN: 2208-2182 )

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