SYNTHESIS OF 2-AMINO-5ALKYL-1,3,4-THIODIAZOLE CATALYZED BY PHALSA JUICE AND ITS ANTIBACTERIAL STUDY
DOI:
https://doi.org/10.53555/s5bptw40Keywords:
Lipophilicity, Thiadiazoles, Antibacterial, S. aureus & E. coli, antitumourAbstract
In contrast of an alkyl chain at the same site mainly adds lipophilicity: 2-amino-5-alkyl-1,3,4-thiadiazoles display solid antibacterial, antifungal and anti-inflammatory effects, yet aryl analogues surpass them in potency across several endpoints. The antibacterial, antitumour, antifungal and antiparasitic assays, because aromatic substitution simultaneously enhances target affinity and cellular uptake. The preparation of 2-amino-5-alkyl-1,3,4-thiadiazoles was accomplished following the established procedure of Arun et. al. Preparation of N-(p-exchanged benzylidene)-5-alkyl-1, 3, 4-thiadiazole-2-amine. N-(p- exchanged benzylidene)-5-alkyl-1,3,4-thiadiazole -2-amine were prepared under the procedure of Bijo Mathew et.al. Antibacterial screening results of 2-Amino-5alkyl-1,3,4-thiodaizole derivatives was screened on bacteria S. aureus & E. coli.
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This work is licensed under a Creative Commons Attribution 4.0 International License
