EPH-International Journal of Applied Science

ANTIOXIDANT AND ANTIPARKINSONIAN ACTIVITY OF ETHANOLIC EXTRACT OF CLITORIA TERNATEA.

Thu, 15 May 2025 00:00:00 +0000

This study investigates the antioxidant and antiparkinsonian potential of the leaf extract of Clitoria ternatea. Oxidative stress is a key contributor to the pathogenesis of Parkinson’s disease, and natural antioxidants derived from medicinal plants offer promising neuroprotective strategies, the ethanolic extract demonstrated significant free radical scavenging activity. Total phenolic and flavonoid contents were quantified and in vitro antioxidant activity of extracts was determined through DPPH scavenging, catalase assay, ferric reducing antioxidant power assay. This study comprehensively evaluated the phytochemical composition, antioxidant potential, and neuroprotective properties of Clitoria terntea leaf extracts. Phytochemical screening and Soxhlet extraction revealed substantial total phenolic content (46.78 mg GAE/g) and moderate flavonoid levels (15.79 mg QE/g). Antioxidant activity was assessed using DPPH assay and hydrogen peroxide radical scavenging assays, ferric chloride antioxidant power assay, ABTS+ scavenging assay which demonstrated notable free radical scavenging capacity. Molecular docking experiments further supported the potential anti-parkinsonian effects of Clitoria Ternatea bioactive constituents, aligning with observed neuroprotective outcomes in experimental models. These findings provide a scientific basis for the traditional use of Clitoria Ternatea in herbal medicine and underscore its promise as a natural source of antioxidants for managing neurological disorders, particularly those linked to oxidative stress. The results advocate for further investigation into the therapeutic applications and mechanisms of Clitoria Ternatea in the context of neurodegenerative disease management.

FORMULATION, DEVELOPMENT AND EVALUATION TESTING OF FOAMING BATH SALT SUBSUMING HIMALAYAN PINK SALT

Janhavi Suryavanshi, Yash Jagtap — Sat, 22 Mar 2025 00:00:00 +0000

This research discusses the formulation and manufacturing of the recently used most popular bath preparation which is bath salt. Centuries ago, people used different salts to soften hard water. During older times, salts were often used for their healing properties. Salts were also quite common in general medicines for treatment of variety of health conditions which includes skin rashes, inflammation, redness, sore muscles, arthritis etc. The concept of bath salts was first raised when the demand of hot spring bath increased rapidly. People used to visit hot spring bath house to soak their body in lukewarm mineral water to relax and calm their body, to cure any clinical conditions and to interact with people for basic communication. The hot spring water is mineral water and holds carbonates and bicarbonates of different minerals. These salts are readily soluble in water and are beneficial for relaxation and curing different conditions. Some people also started using lava stone also known as volcanic stone for many therapies as it is known for its healing properties, relaxation properties and it does have strength to flush out any negative vibes from the body and mind. By researching and combining all the information together, the concept of bath salts has been raised.

This research initially defines the term “BATH SALTS.” Further followed by describing about its purpose of use and its types. Bath salts are used for several purposes such as cleansing, foaming, relaxation, therapeutic treatment and for aesthetic appeal. It helps in healing dermal as well as other clinical conditions. Next it contains the hit and trial method and formula for preparation of bath salts. The main ingredients of the formulated bath salts are Himalayan pink salt, Epsom salt, sodium bicarbonate, some mild surfactants, color, and perfume. All the three salts help to reduce the surface tension of water and helps to cure many skin problems. Finally, it deals with the claims and testing of the same.

SCIENTIFIC VALIDATION AND INTEGRATION OF GARBHAANSKARA INTO MODERN PRENATAL CARE

Dr. Aparna Akhani — Fri, 16 May 2025 00:00:00 +0000

The research analyses the scientific basis of Garbhaanskara, which represents a traditional Indian prenatal concept from Ayurveda that focuses on maternal emotional states combined with direct foetal environmental interactions. The article brings together biomedical evidence alongside classical Indian literature to explain how multiple maternal factors, including stress and psychological status, combined with nutritional inputs and environmental stimulation, influence foetal brain development. These maternal and environmental influences also contribute to genetically modified patterns, which may lead to long-term consequences for future health. The combination of meditation, yoga, music therapy, and mindful nutrition practices described in Garbhaanskara provides documented evidence from neuroscience, obstetrics, and psychology research to support maternal stress reduction, hormone stabilization, and better neurobehavioral development in newborns. Scientific research about prenatal music exposure, alongside studies on mindfulness techniques, along with Ayurvedic nutrition, proves the existence of mechanistic relationships between traditional health practices and measurable maternal-child healthcare benefits. The limitations stem from methodological inconsistencies, small research samples, and the absence of standard measures between investigations, which emphasizes the necessity of conducting randomized controlled studies and international research programs. The review addresses integration obstacles of Garbhaanskara into modern prenatal care while emphasizing educational needs, policy development, and collaborative healthcare practice. The synthesis confirms that Garbhaanskara demonstrates potential to become an effective transformative system of care for maternal and foetal health in our contemporary world because it integrates holistic natural healing practices with cultural sensibility.

DESIGN TRENDS OF HALF-WAVE DIPOLE ANTENNAS IN MATLAB FOR IOT AND WIRELESS COMMUNICATION

Sonu Rani — Sun, 01 Jun 2025 00:00:00 +0000

This review examines the evolution of half-wave dipole antenna designs, mainly through modeling and simulation in MATLAB, for use in Internet of Things (IoT) and wireless systems. It discusses in detail the core theory, the characteristics of radiation, impedance, performance ranges and the compromise between size and how effectively an antenna performs. Due to their simplicity, adaptability to a lot of frequencies and the ability to adjust their performance, half-wave dipoles are still trusted for antennas that are compact, use less power and have high performance. Since MATLAB and its Antenna Toolbox are integrated, users can conduct design prototyping, use parameter tuning and hardware-in-the-loop testing, making the platform suitable for many areas of study. Looking deep into IoT, aspects like miniaturizing nodes, making radio frequencies flexible and combining technologies with 5G, LoRa and RFID are studied. Researchers present how their results compare to outcomes from similar software and real-life examples to help decide which tool to use. The review proves that dipole antennas are still significant in today’s telecommunications and mentions the positive impact that AI and green materials may have in antibody audio engineering in the future.

MERIT OF INDOLE β-DIKETONATES AS SCAFFOLDS IN DRUG DISCOVERY-AN IN SILICO APPROACH USING DISCOVERY STUDIO

Dr. Krishnakumar. K. L, Manju.R, Athira G. L. Nair — Wed, 28 May 2025 00:00:00 +0000

From a medicinal chemist’s viewpoint, two scaffolds can be diverse, if they are built up via different synthetic routes. Synthetic curcumin is one of such scaffold studied and synthesized extensively in different part of word. Though many analogues were patented, major pitfalls in curcumin chemistry without a significant therapeutic agent requires attention. The existing multi directional studies in the last forty-plus years with diverse curcumin templates are to be analyzed to find out the most suitable scaffold among them. It is a high time to investigate, test and hypotheses in silico prior to costly random experimental implementation of synthetic curcumin. The diverse approach existed in SAR based synthesis and the existing numerous synthetic approaches should be streamlined for reducing the time and expense involved in bringing products to market. So, this study focuses on collection and in silico screening of existing templates of “curcumin research” for cyto toxicity receptor binding. It further continues with identification and enlightenment on highly disputed pharmacophore in curcumin, which is responsible for high potential cytotoxic action. The aim of curcumin scaffold hoping is to synthesis structurally novel compound from the identified templates by in silico method and to explore the core structures ability to bind with the most suitable receptor. The second part of work is on modifying synthetic route, which make it appropriate for synthesizing the series of compounds from most eligible drug candidate. At the same time, parallel to these acute toxicity studies of these sequences of compound was conducted in the aim of bringing a safe analogue. Curcumin research, which turned out to be one of the preferred subjects for organic, inorganic chemists should need a direction. By this scaffold hoping and in silico analysis on available synthetic analogues for a given target will definitely give light on ability of these diverse compounds to bind on same receptor. The in vivo and in vitro studies help in exploring the effect of modification on pharmacophore features of identified eligible drug candidate. Scaffold hopping will be an excellent method to be experimented in this juncture of curcumin research

IBOT SURVEILLANCE ROBOT

Fri, 07 Mar 2025 00:00:00 +0000

In a time when security and surveillance are the new buzzword, the IBOT Surveillance Robot offers 'an innovative solution that unites robotics, artificial intelligence and IoT connectivity. Featuring an Arduino Nano microcontroller, an ESP32-CAM real-time video streaming processor, and advanced sensors such as PIR (for sound detection), gas, flame, accelerometer, noise cancellation; and environmental sensor arrays, this autonomous robotic system is designed for precise monitoring in military, industrial or domestic applications. It has been developed to meet demanding high-precision standards. Bluetooth and Wi-Fi are both used by the robot to enable remote operation as well as transmitting data. In this paper, the system's architecture, innovative design methodology and optimized energy management strategies are thoroughly analysed. Extensive experimental testing confirms the robot's suitability for different environments, demonstrating high accuracy in detecting threats, exceptional power efficiency, and reliable autonomous navigation. The IBOT Surveillance Robot's real-time data processing, security flaws, and power requirements are the key factors that set it apart from other autonomous surveillance systems. It is scalable to modern security infrastructures and will be an intelligent asset in future with improvements such as AI-led anomaly detection, navigation via SLAM on the cloud, or cloud-integrated remote monitoring.

"When intelligence meets motion, vigilance becomes seamless, and security transforms from a mere concept into an unwavering presence."

FIBROADENOMA TREATMENT WITH LEKHANA AND SHOTHHARA TREATMENT

Dr. Aparna Akhani — Tue, 13 May 2025 00:00:00 +0000

Fibroadenomas among young women create substantial clinical and psychological challenges as part of benign breast disorders worldwide. Patients seek alternative remedies due to technological disadvantages, recurrence concerns, and aesthetic considerations that affect surgical treatments of benign breast disorders. The ancient Indian medical system of Ayurveda promotes effective treatments for benign breast conditions through individualized non-invasive methods of Lekhana scraping and Shothhara anti-inflammatory procedures. A review presents evidence of how classical Ayurvedic concepts link to current pharmacological findings to establish their clinical importance in fibroadenoma therapy. The Lekhana therapeutic approach uses Kanchanar, Guggulu, and Triphala herbs to deliver effective anti-proliferative, antioxidant, and mass-reducing benefits. Shothhara therapies that include Haridra, Shallaki, Guduchi, and Punarnava demonstrate anti-inflammatory and immunomodulatory properties, helping control the inflammatory conditions found in benign breast lesions. A limited number of clinical studies and observational reports indicate potential beneficiary effects of treatment, which stabilize breast lesions and reduce their size while alleviating symptoms; however, authors call for substantial trials based on methodological standards. Clinical research that combines traditional knowledge with modern scientific research should be prioritized for validating Ayurvedic therapies to optimize their effectiveness in fibroadenoma patient care