EPH-International Journal of Applied Science

MERIT OF INDOLE β-DIKETONATES AS SCAFFOLDS IN DRUG DISCOVERY-AN IN SILICO APPROACH USING DISCOVERY STUDIO

Dr. Krishnakumar. K. L, Manju.R, Athira G. L. Nair — Wed, 28 May 2025 00:00:00 +0000

From a medicinal chemist’s viewpoint, two scaffolds can be diverse, if they are built up via different synthetic routes. Synthetic curcumin is one of such scaffold studied and synthesized extensively in different part of word. Though many analogues were patented, major pitfalls in curcumin chemistry without a significant therapeutic agent requires attention. The existing multi directional studies in the last forty-plus years with diverse curcumin templates are to be analyzed to find out the most suitable scaffold among them. It is a high time to investigate, test and hypotheses in silico prior to costly random experimental implementation of synthetic curcumin. The diverse approach existed in SAR based synthesis and the existing numerous synthetic approaches should be streamlined for reducing the time and expense involved in bringing products to market. So, this study focuses on collection and in silico screening of existing templates of “curcumin research” for cyto toxicity receptor binding. It further continues with identification and enlightenment on highly disputed pharmacophore in curcumin, which is responsible for high potential cytotoxic action. The aim of curcumin scaffold hoping is to synthesis structurally novel compound from the identified templates by in silico method and to explore the core structures ability to bind with the most suitable receptor. The second part of work is on modifying synthetic route, which make it appropriate for synthesizing the series of compounds from most eligible drug candidate. At the same time, parallel to these acute toxicity studies of these sequences of compound was conducted in the aim of bringing a safe analogue. Curcumin research, which turned out to be one of the preferred subjects for organic, inorganic chemists should need a direction. By this scaffold hoping and in silico analysis on available synthetic analogues for a given target will definitely give light on ability of these diverse compounds to bind on same receptor. The in vivo and in vitro studies help in exploring the effect of modification on pharmacophore features of identified eligible drug candidate. Scaffold hopping will be an excellent method to be experimented in this juncture of curcumin research

IBOT SURVEILLANCE ROBOT

Fri, 07 Mar 2025 00:00:00 +0000

In a time when security and surveillance are the new buzzword, the IBOT Surveillance Robot offers 'an innovative solution that unites robotics, artificial intelligence and IoT connectivity. Featuring an Arduino Nano microcontroller, an ESP32-CAM real-time video streaming processor, and advanced sensors such as PIR (for sound detection), gas, flame, accelerometer, noise cancellation; and environmental sensor arrays, this autonomous robotic system is designed for precise monitoring in military, industrial or domestic applications. It has been developed to meet demanding high-precision standards. Bluetooth and Wi-Fi are both used by the robot to enable remote operation as well as transmitting data. In this paper, the system's architecture, innovative design methodology and optimized energy management strategies are thoroughly analysed. Extensive experimental testing confirms the robot's suitability for different environments, demonstrating high accuracy in detecting threats, exceptional power efficiency, and reliable autonomous navigation. The IBOT Surveillance Robot's real-time data processing, security flaws, and power requirements are the key factors that set it apart from other autonomous surveillance systems. It is scalable to modern security infrastructures and will be an intelligent asset in future with improvements such as AI-led anomaly detection, navigation via SLAM on the cloud, or cloud-integrated remote monitoring.

"When intelligence meets motion, vigilance becomes seamless, and security transforms from a mere concept into an unwavering presence."

FORMULATION, DEVELOPMENT AND EVALUATION TESTING OF FOAMING BATH SALT SUBSUMING HIMALAYAN PINK SALT

Janhavi Suryavanshi, Yash Jagtap — Sat, 22 Mar 2025 00:00:00 +0000

This research discusses the formulation and manufacturing of the recently used most popular bath preparation which is bath salt. Centuries ago, people used different salts to soften hard water. During older times, salts were often used for their healing properties. Salts were also quite common in general medicines for treatment of variety of health conditions which includes skin rashes, inflammation, redness, sore muscles, arthritis etc. The concept of bath salts was first raised when the demand of hot spring bath increased rapidly. People used to visit hot spring bath house to soak their body in lukewarm mineral water to relax and calm their body, to cure any clinical conditions and to interact with people for basic communication. The hot spring water is mineral water and holds carbonates and bicarbonates of different minerals. These salts are readily soluble in water and are beneficial for relaxation and curing different conditions. Some people also started using lava stone also known as volcanic stone for many therapies as it is known for its healing properties, relaxation properties and it does have strength to flush out any negative vibes from the body and mind. By researching and combining all the information together, the concept of bath salts has been raised.

This research initially defines the term “BATH SALTS.” Further followed by describing about its purpose of use and its types. Bath salts are used for several purposes such as cleansing, foaming, relaxation, therapeutic treatment and for aesthetic appeal. It helps in healing dermal as well as other clinical conditions. Next it contains the hit and trial method and formula for preparation of bath salts. The main ingredients of the formulated bath salts are Himalayan pink salt, Epsom salt, sodium bicarbonate, some mild surfactants, color, and perfume. All the three salts help to reduce the surface tension of water and helps to cure many skin problems. Finally, it deals with the claims and testing of the same.