ANTIHISTAMINIC PROPERTY OF SOLANUM XANTHOCARPUM AND ITS PHYTOCONSTITUENTS
DOI:
https://doi.org/10.53555/x6jbxy69Keywords:
Histamine, Immune response, Histamine blockers, Mastcell, allergic asthmaAbstract
Now a days there has been steady increase in the prevalence allergic immune response involving immune cells and mediators. The key role in the immune cascade is taken by histamine. It is natural component of the body, which in the allergic inflammatory response is released by the mast cells and basophils. Compound Sx-7 isolated from alcoholic extract of S. xanthocarpum as white crystals (m.p. 164ºC) U.V., 1H NMR and mass spectroscopy of this compound is similar to spectral data of stigmasterol. Active phytoconstituents Solasodine also extracted from alcoholic extract which play an important role for altering concentration in human body. In comparison with standard drug DSCG alcoholic extract protect degranulation of mast cell at dose of 50 mg & 100 mg/kg b.w. 74.39% and 78.26% respectively. Solasodine protect 79.48% and 84.38% at a dose of 1.0mg & 2.0 mg/kg b.w. significantly. Histamine causes branchoconstriction by activating H1-receptors. Eosinophilia is abnormal increase in the peripheral eosinophil count especially in the development of allergic asthma. Stabilization of mast cell by alcoholic extract of S. xanthocarpum at a dose of 50mg & 100 mg/kg b.w., i.p. shown percentage protection of 74.39% and 78.26% respectively as compared to standard drug DSCG 83.81%. Active constituent Solasodine protection percentage was found 79.48 and 84.38 at dose of 1.0mg and 2.0 mg/kg b.w. significantly.
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