INVESTIGATION OF THE EFFECT OF GINGER ON THE LIPID LEVELS AGAINST THE TOXIC EFFECT OF PHTHALATE IN MALE RABBITS

Authors

  • Fayrouz A. Khaled Chemistry Department, Faculty of Science, Omar El-Mokhtar University, El Beyda, Libya.
  • Mokhtar. I . Yousef Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
  • Abdel-Aziz F. Abdel-Aziz Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
  • Hanaa A. Hassan Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
  • Kamel. I. kamel Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt

DOI:

https://doi.org/10.53555/eijas.v2i2.140

Keywords:

Ginger, phthalate, cholesterol, New-Zealand white rabbits

Abstract

This study was designed to investigate the adverse effects of Di-(2ethylhexylphthalate (DEHP) the levels of total protein (TP), total lipids (TL), total cholesterol (TC), triglyceride (TG), high and low-density lipoprotein-cholesterol (HDL-c and LDL-c) in blood plasma in male New-Zealand white rabbits. Additionally, the study was extended to show the protective effect of ginger against DEHP toxicity.  The levels of TL, TC, TG and LDL-c were significantly (P<0.05) increased, while HDL-c and TP were significantly (P<0.05) decreased in plasma of rabbits treated with DEHP alone as compared with control group. The levels of TL, TC, TG and LDL-c were significantly (P<0.05) decreased while HDL-c and TP was significantly (P<0.05) increased in rabbits treated with ginger alone as compared to control animals. The presence of ginger with DEHP caused significant (P<0.05) decrease in the induction in the levels of TL, TC, TG and HDL-c, and significant (P<0.05) increase in the reduction TP and LDL-c due to treatment with DEHP, and this means that ginger had protective effect against the toxicity of DEHP .

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Published

2016-06-27

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Vol. 2 No. 2 (2016): EPH - International Journal of Applied Science ( ISSN: 2208-2182 )

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